The Four Horsemen of the Apocalypse

The real Four Horsemen of the Apocalypse are:

Ignorance
Want
Overpopulation
Religion, in the way it fosters, abets and uses the problems above to validate itself

As for religion, I generally believe in the words of HL Mencken.

The Mencken Creed

I believe that religion, generally speaking, has been a curse to mankind - that its modest and greatly overestimated services on the ethical side have been more than overcome by the damage it has done to clear and honest thinking.

I believe that no discovery of fact, however trivial, can be wholly useless to the race, and that no trumpeting of falsehood, however virtuous in intent, can be anything but vicious.

I believe that all government is evil, in that all government must necessarily make war upon liberty.

I believe that the evidence for immortality is no better than the evidence of witches, and deserves no more respect.

I believe in the complete freedom of thought and speech.

I believe in the capacity of man to conquer his world, and to find out what it is made of, and how it is run.

I believe in the reality of progress.

I believe that it is better to tell the truth than to lie. I believe that it is better to be free than to be a slave. And I believe that it is better to know than be ignorant.

-HL Mencken, writer, critic, journalist (1880-1956)